![]() Impairment in either domain was modestly correlated with the Fried frailty phenotype (CIB, ρ = 0.177 delayed recall, ρ = 0.170 P = .01 for both), and many phenotypically robust patients also had probable cognitive impairment (24 of 104 on CIB and 9 of 104 on delayed recall). One hundred twenty-seven patients (35.3%) had probable executive dysfunction on the CIB, and 62 (17.2%) had probable impairment in working memory on the 5-word delayed recall. Results Among 420 consecutive patients approached, 360 (85.7%) agreed to undergo frailty assessment (232 men and 128 women mean age, 79.8 years), and 341 of those (94.7%) completed both cognitive screening tests. The Fried frailty phenotype and Rockwood cumulative deficit model of frailty were also assessed to characterize participants as robust, prefrail, or frail. A 5-word delayed recall test was used to screen for impairment in working memory. Patients underwent screening for frailty and cognitive dysfunction and were followed up for survival.Įxposures The Clock-in-the-Box (CIB) test was used to screen for executive dysfunction. Objective To determine the prevalence of domain-specific cognitive impairment and its association with overall survival among older patients with blood cancer.ĭesign, Setting, and Participants This prospective observational cohort study included all patients 75 years and older who presented for initial consultation in the leukemia, myeloma, or lymphoma clinics of a large tertiary hospital in Boston, Massachusetts, from February 1, 2015, to March 31, 2017. Little is known about how specific domains of cognitive impairment may be associated with survival among older patients with hematologic cancers. Importance As the population ages, cognitive impairment has promised to become increasingly common among patients with cancer.
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